Dichloroacetyl chloride → HCID 57085216, compound

Participants

Reaction Steps

A 3-neck, 5 L flask equipped with a heating mantle, a mechanical stirrer, an argon inlet, and a pressure-equalized dropping funnel was charged with the 6-(tert-butyldimethylsilyloxy)fulvene from the previous Preparation dissolved in 2 L of cyclohexane. After this solution was brought to reflux, 150 mL of triethylamine was added in one portion. Then, 100 mL of dichloroacetyl chloride was added dropwise to the refluxing mixture over a 1.5 hr period. The cooled reaction mixture was diluted with 1.5 L of methylene chloride and filtered to remove the triethylamine hydrochloride by-product. The dark solution of the crude reaction product could be stored as such for a few days. The solvent was removed by evaporation immediately before its use in the next reaction.

Provenance & Evidence