反应详情

A 500 mL, 3-neck flask fitted with an argon inlet, septum cap, thermometer, and stir bar was charged with 7.2 g of 3-phenylthio-7-oxobicyclo[3.2.0]heptan-2-carboxylic acid, diphenylmethyl ester, prepared by the procedure of Paragraph A, dissolved in 200 mL of methylene chloride. To this rapidly stirred solution at -65° was added 5.7 mL of pyridine in one portion, then 1.85 mL of sulfonyl chloride dropwise, slowly. This solution was stirred between -60° and -55° C. for 30 min and then it was poured onto water. The organic phase was washed again with water, then with brine dried over sodium sulfate and evaporated to dryness. The two major components of this mixture was separated on a Waters prep LC/System 500 liquid chromatograph by elution on 2 silica gel cartridges with methylene chloride. The second major component to be eluted was 3-phenylthio-7-oxobicyclo[3.2.0]hept-2-en-2-carboxylic acid, diphenylmether ester, 3.46 g (48.3%) as a colorless solid: NMR (220 MHz; CDCl3): δ 2.27 (1 H, dd, J=17, 3.5), 2.6-3.0 (3H, m), 3.18 (1H, ddd, J=17, 8, 4), 4.57 (1H, m), 6.84 (1H, s), and 7.0-7.5 (15H, m). The analytical sample, mp 148° to 150°, was prepared by recrystallization from benzene-ether.

1. customA 500 mL, 3-neck flask fitted with an argon inlet
2. customseptum cap
3. customprepared by the procedure of Paragraph A
4. stirringThis solution was stirred between -60° and -55° C. for 30 min
5. additionit was poured onto water
6. washThe organic phase was washed again with water
7. dry with materialwith brine dried over sodium sulfate
8. customevaporated to dryness
9. customThe two major components of this mixture was separated on a Waters prep LC/System 500 liquid chromatograph by elution on 2 silica gel cartridges with methylene chloride
10. washThe second major component to be eluted
11. customThe analytical sample, mp 148° to 150°, was prepared by recrystallization from benzene-ether