HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Quinoline, 2-phenyl-4-(2-(1-(2-phenylethyl)-4-piperidinyl)ethyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Phenethyl bromide | HCID 7666 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Phenyl-4-(2-(4-piperidinyl)ethyl)quinoline | HCID 71219 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Quinoline, 2-phenyl-4-(2-(1-(2-phenylethyl)-4-piperidinyl)ethyl)- | HCID 3062095 | — |
Reaction Steps
The operation is as in Example 21, starting from 9.3 g of the monohydrochloride of 2-phenyl-4-[2-(4-piperidyl)-ethyl]-quinoline, prepared as indicated in Example 16, 7.3 g of 2-phenyl-ethyl bromide and 18.1 g of potassium carbonate, in suspension in 130 ml of dimethylformamide. 8.3 g are obtained of 4-{2-[1-(2-phenyl-ethyl)-4-piperidyl]-ethyl}-2-phenyl-quinoline melting at 80° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04505916 |
| Source dataset | uspto-grants-1985_03 |
| ORD ID | ord-3ae3161932dc4ef7b0bc41b848a0b799 |
| Source note | uspto-grants-1985_03 |