Tetrahydrofuran → HCID 13335597, compound

Participants

Reaction Steps

12.35 parts of 3-chloro-3-phenyl-1-(3H)-isobenzofuranone in solution in 40 parts of anhydrous tetrahydrofuran are added, while stirring, over a period of approximately 15 minutes, to a solution of 10 parts of para-(β-aminoethyl)benzenesulphonamide and 5.06 parts of triethylamine in 80 parts of anhydrous dimethylformamide. The temperature rises from 25° to 50° C. and after being stirred for 2 hours the reaction mixture is diluted in 400 parts of water. The precipitate formed is suction-filtered and dried in air and then recrystallized in 360 parts of isopropanol. 12 parts of para-[β-(2,3-dihydro-3-hydroxy-3-phenyl-(1H)-isoindol-1-on-2-yl)ethyl]benzenesulphonamide are obtained melting at 225° C.

Provenance & Evidence