HCID 13335597, compound → HCID 13335608, compound

HRID 2164611Notes

Reaction equation

HRID 2164611 reaction equation
O[C:2]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:16][CH:15]=1>C(O)=O>[C:24]1([CH:2]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[C:4](=[O:11])[N:3]2[CH2:12][CH2:13][C:14]2[CH:15]=[CH:16][C:17]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:18][CH:19]=2)[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 1

HCID 13335597HCID 13335597, compound

Product 1

HCID 13335608HCID 13335608, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

12 parts of para-[β-(2,3-dihydro-3-hydroxy-3-phenyl-(1H)-isoindol-1-on-2-yl)ethyl]benzenesulphonamide are refluxed for 7 hours with 120 parts of 98% formic acid. After concentration in vacuo, the residue is recrystallized in 110 parts of ethyl acetate to give 8 parts of the desired product, m.p.: 218° C.

Workup

  1. concentrationAfter concentration in vacuo
  2. customthe residue is recrystallized in 110 parts of ethyl acetate

Sources & evidence

ORD record
ord-c43ec352d2d54509a38e961ff124c1f8
Source dataset
uspto-grants-1985_03
Patent number
US04505921

Reaction notes

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