Tert-Butylamine → HCID 13473211, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 6-(2,3-epoxypropoxy)benzothiazole-2-sulfonamide (1.14 gm, 4.0 mmol) in acetonitrile (16 mL) and methanol (4 mL) containing t-butylamine (0.88 mL, 0.4 mmol) was warmed at 50° C. for 15-20 hours. The solvents were evaporated and the residue (1.1 gm) was chromatographed on silica gel eluting with 20-30% methanol/chloroform (V/V). The appropriate fractions were combined and evaporated. The residue was digested in acetonitrile, cooled and the produce collected (0.62 gm), m.p. 195°-196° C.

Provenance & Evidence