反应详情

A solution of 1-acetyl-2-(4-carbomethoxy-2,6-dichlorophenylimino)imidazolidine (5 g, 15 mmole) and 2M hydrochloric acid (1 ml, 2 mmole) in methanol (100 ml) was heated under reflux for 40 hour. The mixture was then evaporated to give a solid which was taken up in methylene chloride/methanol (650 ml:30 ml) and extracted with saturated sodium carbonate (300 ml). The organic layer was dried and evaporated to give a residue which after trituration with ether, yielded the title compound as a solid (3.5 g) mp 229°-231° C.

1. temperatureunder reflux for 40 hour
2. customThe mixture was then evaporated
3. customto give a solid which
4. extractionextracted with saturated sodium carbonate (300 ml)
5. customThe organic layer was dried
6. customevaporated
7. customto give a residue which after trituration with ether