HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dichlorophenol → 1,2-Dichloro-4-(3-methyl-4-(methylsulfonyl)phenoxy)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dichlorophenol | HCID 7258 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Chloro-2-methyl-1-(methylsulfonyl)benzene | HCID 20405099 | — |
| Solvent | Sulfolane | HCID 31347 | — |
| Product | 1,2-Dichloro-4-(3-methyl-4-(methylsulfonyl)phenoxy)benzene | HCID 514873 | 63.4% |
Reaction Steps
A slurry of 6.14 g of 4-chloro-2-methylphenyl methyl sulfone, 8.35 g of 3,4-dichlorophenol and 7.08 g of K2CO3 in 150 ml of sulfolane was heated at 170° C. for 7 hrs. The product (6.3 g, 63.4% yield) was isolated from the reaction mixture essentially as described in Example 18. Recrystallization from ethanol afforded purified 4-(3-methyl-4-(methylsulfonyl)phenoxy)-1,2-dichlorobenzene, mp 154°-156° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04505929 |
| Source dataset | uspto-grants-1985_03 |
| ORD ID | ord-eb3fc38cb41b4e1cb7a4a638628381e2 |
| Source note | uspto-grants-1985_03 |