1-Chloro-4-(methylsulfonyl)benzene → 1-(4-(Methylsulfonyl)phenoxy)-4-(phenylmethyl)benzene

Participants

Reaction Steps

A slurry of 5.72 g of 4-chlorophenyl methyl sulfone, 6.08 g of 4-benzylphenol and 4.56 g of K2CO3 in 150 ml of DMSO was heated at 160° C. for 8.5 hrs. The product (9.55 g, 94.1% yield) was recovered from the reaction mixture essentially as described in Example 18. Recrystallization from 2-propanol and then from aqueous acetic acid afforded purified 1-(4-(methylsulfonyl)phenoxy)-4-(phenylmethyl)benzene, mp 109°-110° C.

Provenance & Evidence