2,2,6,6-Tetramethyl-4-piperidone → N-(2,2,6,6-tetramethyl-4-piperidylidene)-2-methylallylamine

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Reaction Steps

400 g of 2-methylallylamine are dissolved in 400 ml of toluene in a 2.5 liter sulfonating flask, and 450 g of microfilter are added. A solution of 700 g of 2,2,6,6-tetramethyl-4-piperidone in 300 ml of toluene is then added dropwise in such a manner that the reaction temperature is kept at 30°-35° C. After the addition is completed, stirring is maintained for 6 hours at room temperature. The mixture is filtered off from the microfilter, and the solvent is removed in a rotary evaporator. Distillation of the residue yields 778 g of N-(2,2,6,6-tetramethyl-4- piperidylidene)-2-methylallylamine, corresponding to 83% of theory, in the form of a colourless liquid having a boiling point of 63° C. at 40 Pa.

Provenance & Evidence