Methanethiol → HCID 13088591, compound

Participants

Reaction Steps

10 g (0.2 mol) of methylmercaptan were introduced into a solution of 0.5 g (9 millimol) of sodium methylate in 300 ml of ethanol. 47 g (0.16 mol) of 1-(4-chloro-phenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)-pent-1-en-3-one (E isomer) were introduced into this solution. The initially clear solution soon changed to a thick crystal slurry. The crystals were filtered off, washed with diisopropyl ether and with ethanol, and dried. 36 g (66.6% of theory) of 1-(4-chlorophenyl)-4,4-dimethyl-1-methylthio-2-(1,2,4-triazol-1-yl)-pentan-3-one of melting point 145° C. were obtained.

Provenance & Evidence