Sodium borohydride → HCID 13088604, compound

Participants

Reaction Steps

9.5 g (25 millimols) of 4,4-dimethyl-1-(4-fluorophenyl)-1-phenylthio-2-(1,2,4-triazol-1-yl)-pentan-3-one (Example 3) were suspended in 150 ml of isopropyl alcohol and 0.5 g (12.5 millimols) of sodium borohydride were added in portions. After 2 days, the mixture was evaporated down in vacuo and the residue was decomposed with dilute acetic acid. The organic phase was taken up in methylene chloride, and the methylene chloride solution was washed with water, dried over sodium sulphate, filtered and evaporated down in vacuo. The crystalline residue was stirred with diisopropyl ether; the crystals were filtered off and dried. 7.5 g (77.9% of theory) of 4,4-dimethyl-1-(4-fluorophenyl)-1-phenylthio-2-(1,2,4-triazol-1-yl)-pentan-3-ol, of melting point 171° C., were obtained.

Provenance & Evidence