Ethanethiol → HCID 13088595, compound

Participants

Reaction Conditions

Reaction Steps

4.4 ml (0.059 mol) of ethylmercaptan were added to a suspension of 3.19 g (0.059 mol) of sodium methylate in 200 ml of diethyl ether. After 2 hours, 20.2 g (0.059 mol) of 1-(2,4-dichlorophenyl)-4,4-dimethyl-5-fluoro-2-(1,2,4-triazol-1-yl)-pent-1-en-3-one (E isomer) were introduced. The mixture was stirred for 18 hours at 25° C. and was then evaporated down in vacuo. The residue was introduced into water and the mixture was extracted with methylene chloride. The methylene chloride solution was dried over sodium sulphate, filtered and evaporated down in vacuo. The oil which remained was caused to crystallize by stirring with diisopropyl ether. 13 g (54.6% of theory) of 1-(2,4-dichlorophenyl)-4,4-dimethyl-1-ethylthio-5-fluoro-2-(1,2,4-triazol-1-yl)-pentan-3-one, of melting point 130° C., were obtained.

Provenance & Evidence