Acetone → HCID 13088605, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 0.42 g (11 millimols) of sodium boranate in 20 ml of water was added dropwise, with stirring, to a suspension of 6.4 g (15.8 millimols) of 1-(2,4-dichlorophenyl)-4,4-dimethyl-1-ethylthio-5-fluoro-2-(1,2,4-triazol-1-yl)-pentan-3-one (see Example 5) and 1.2 g (10.8 millimols) of calcium chloride in 150 ml of isopropanol. The mixture was stirred for 18 hours at 0° C. and 20 ml of acetone were then added dropwise. This mixture was evaporated in vacuo and the residue was decomposed with dilute acetic acid. The organic base was dissolved in methylene chloride and the solution was washed with water, dried over sodium sulphate, filtered and evaporated down in vacuo. The oil which remained was stirred with diisopropyl ether. 3.9 g (60% of theory) of 1-(2,4-dichlorophenyl)-4,4-dimethyl-1-ethylthio-5-fluoro-2-(1,2,4-triazol-1-yl)-pentan-3-ol, of melting point 182° C., were obtained.

Provenance & Evidence