Ethanol → HCID 13116734, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7.5 g of 4-{4-[2-(1-imidazolyl)-ethyl]-phenyl}-4-oxo-butyric acid methyl ester, 0.2 g of barium oxide, 1.3 g of hydrazine hydrate and 30 ml of ethanol is stirred at 0° C. for 10 minutes and then at room temperature for 2 hours, and is subsequently heated under reflux for 1 hour. The reaction mixture is diluted with water and extracted with chloroform and the extract is washed with water and dried over Na2SO4. The solvent is stripped off and the residue is purified by column chromatography (silica gel/chloroform/methanol).

Provenance & Evidence