Sodium Hydroxide → 4-{4-[4-(1-Imidazolyl)-butyl]phenyl}-4-oxo-butyric acid

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Reaction Steps

15 g of 4-{4-[4-(1-imidazolyl)-butyl]-phenyl}-4-oxo-butyric acid methyl ester are dissolved in 180 ml of methanol, and 2.3 g of sodium hydroxide, dissolved in a little methanol, are added. The mixture is stirred at room temperature for 24 hours, the solvent is stripped off and the residue is taken up in water. The solution is extracted several times with chloroform and the chloroform phase is discarded. The aqueous solution is adjusted to about pH 6 with dilute hydrochloric acid and the solid which has precipitated is filtered off with suction, washed with a little water and dried.

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