Chloroacetone → 8-Chloro-2-methylimidazo[1,2-a]pyrazine

HRID 2164735Notes

Reaction equation

[NH2:1][C:2]1[C:7]([Cl:8])=[N:6][CH:5]=[CH:4][N:3]=1.Cl[CH2:10][C:11](=O)[CH3:12]>>[Cl:8][C:7]1[C:2]2[N:3]([CH:10]=[C:11]([CH3:12])[N:1]=2)[CH:4]=[CH:5][N:6]=1

Participants

Reactant 2

HCID 6571Chloroacetone

HCID 2762242-Amino-3-chloropyrazine

Product 1

HCID 133890828-Chloro-2-methylimidazo[1,2-a]pyrazine

Procedure

For example, condensation of a 2-amino-3-chloropyrazine with chloroacetone gives an 8-chloro-2-methylimidazo[1,2-a]pyrazine as shown the following reaction Scheme II. ##STR14##

Sources & evidence

ORD record: ord-0639eeff4a59408b871f218ee1017eb8
Source dataset: uspto-grants-1985_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04507294

Reaction notes

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