Butyl nitrite → HCID 20403190, compound

Participants

Reaction Steps

A solution of 14.2 g 2-methyl-8-phenylmethoxyimidazo[1,2-a]pyrazine, 129.3 g n-butyl nitrite and 142 ml p-dioxane was heated under reflux for 0.5 hr. and decanted from a small amount of gum. The supernatant solution was stirred under vacuum (40°/0.1 mm) and the residue azeotroped with cyclohexane to give 2-methyl-3-nitroso-8-phenylmethoxyimidazo[1,2-a]pyrazine as a soft, green solid which was identified by pmr and ms and immediately reduced (as in Example 6) without further purification.

Provenance & Evidence