1,4-Dichlorobenzene → 4-Methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione

Participants

Reaction Steps

To a mixture of 8 ml. of oxalyl chloride in 150 ml. dichlorobenzene at 60° C. was added lowly 7.5 g. of 2-amino-3-methylaminopyridine. After completion of addition, the temperature of the reaction mixture was allowed to rise to 130° C. It was stirred at this temperature for 1 hour, filtered hot, and the solid washed with ether, m.p. 168°-174° C.

Provenance & Evidence