N-Methylisatoic anhydride → N-[3-(1H-Imidazol-1-yl)propyl]-2-(methylamino)benzamide

Participants

Reaction Steps

N-Methylisatoic anhydride (17.7 g) was added in portions to a stirred solution of 3-imidazol-1-ylpropylamine (12.5 g) in dioxan (150 ml) over a period of 15 minutes. Stirring was continued for 40 minutes before the solution was evaporated in vacuo to give 2-methylamino-N-(3-imidazol-1-ylpropyl)benzamide (18.0 g), in the form of a buff coloured solid, m.p. 138°-141° C., after recrystallisation from isopropanol.

Provenance & Evidence