5-Chloroisatoic anhydride → 2-Amino-5-chloro-N-[3-(1H-imidazol-1-yl)propyl]benzamide

Participants

Reaction Steps

5-Chloroisatoic anhydride (26.7 g) was added in portions to a stirred solution of 3-imidazol-1-ylpropylamine (17.2 g) in dioxan (150 ml) over a period of 15 minutes. Stirring was continued for 40 minutes before the solution was evaporated in vacuo to give 5-chloro-2-amino-N-(3-imidazol-1-ylpropyl)benzamide as a buff coloured solid, used without further purification.

Provenance & Evidence