Dimethylformamide → trans-3-(2,2-Difluoroethenyl)-2,2-dimethylcyclopropanecarbonylchloride

Participants

Reaction Steps

A stirred solution of trans-3-(2,2-difluoroethenyl)-2,2-dimethylcyclopropanecarboxylic acid (2.0 g; 0.0114 mole) and N,N-dimethylformamide (0.08 g) in 20 ml of dry diethyl ether was cooled to 0° C. A solution of oxalyl chloride (2.17 g; 0.017 mole) in 2 ml of dry diethyl ether was added to the reaction mixture during a 20 minute period. Upon complete addition the mixture was allowed to warm to room temperature and stir for two hours. The mixture was concentrated under reduced pressure to give a yellow oil. The oil was dissolved in 5 ml of dry diethyl ether and the solvent removed under reduced pressure to yield trans-3-(2,2-difluoroethenyl)-2,2-dimethylcyclopropanecarbonylchloride as an oil.

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