2-Aminobenzoxazole → HCID 178515424, compound

Participants

Reaction Steps

A mixture of 1.34 g (10.0 mmole) of 2-aminobenzoxazole, 1.56 g (10.0 mmole) of ethyl tetrazol-5-ylacetate, 1.65 g (11.1 mmole) of triethyl orthoformate and 0.3 g (2.2 mmole) of aluminum trichloride in 25 ml of 1,1,2,2-tetrachloroethane was heated under a nitrogen atmosphere at 125° to 130° C. for about 19 hours. The mixture was cooled and the resulting solid was separated by filtration and washed with methanol to provide 0.72 g (28%) of crude-3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzoxazol-4-one. Infrared spectral analysis of the crude product showed that it was the desired product.

Provenance & Evidence