HCID 13455633, compound → HCID 23700899, compound

Participants

Reaction Steps

Under cooling with ice, a 0.48N sodium hydroxide-ethanol solution (54.2 ml) was added dropwise to an ethanol solution (70 ml) of ethyl trans-3-[(s)-1-(4-diphenylmethylpiperazine-1-yl carbonyl)-3-methylbutyl carbamoyl]oxirane-2-carboxylate (13.2 g) obtained above. After stirring at room temperature for 3 hours, the solvent was removed by distillation under reduced pressure, and the reaction mixture was further dried under reduced pressure to yield 12.4 g of sodium trans-3-[(s)-1-(4-diphenylmethylpiperazine-1-yl carbonyl)-3-methylbutylcarbamoyl]oxirane-2-carboxylate as a light yellow powder (yield: 95%).

Provenance & Evidence