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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2164876Generated: October 30, 2026

1-((4-Methoxyphenyl)methyl)piperazine → HCID 53740006, compound

https://huagongshe.com/reaction/2164876

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-((4-Methoxyphenyl)methyl)piperazineHCID 231905—
ReactantN-Boc-L-Leucine HydrateHCID 12373896—
ReactantHCID 13455629HCID 13455629—
ProductHCID 53740006HCID 5374000695.5%

Reaction Steps

Tert-butoxycarbonyl-L-leucine monohydrate (7.47 g) and 1-(4-methoxy-phenylmethyl)piperazine (6.18 g) were condensed in the same manner as employed in the preparation of tert-butyl (s)-1-(4-diphenylmethylpiperazine-1-yl carbonyl)-3-methylbutylcarbamate to yield 12.0 g of tert-butyl (s)-1-[4-(4-methoxyphenylmethyl)piperazine-1-yl carbonyl]-3-methylbutylcarbamate as a colorless amorphous substance (yield: 95%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04507297
Source datasetuspto-grants-1985_03
ORD IDord-11d6d1e887c647bda282b6d6b02e2c1c
Source noteuspto-grants-1985_03