HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalic acid dihydrate → HCID 86740006, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalic acid dihydrate | HCID 61373 | — |
| Reactant | Ethyl (2R,3R)-3-{[(2S)-4-methyl-1-oxo-1-{4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl}pentan-2-yl]carbamoyl}oxirane-2-carboxylate | HCID 6917749 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 86740006 | HCID 86740006 | 81.6% |
Reaction Steps
An acetone solution (2 ml) of oxalic acid dihydrate (0.25 g) was added to an acetone solution (6 ml) of ethyl (2R,3R)-3-[(s)-3-methyl-1-{4-(2,3,4-trimethoxyphenylmethyl)piperazine-1-yl carbonyl}butylcarbamoyl]oxirane-2-carboxylate (1.04 g), and the crystal which had precipitated was collected by filtration and dried to yield 0.99 g of ethyl (2R,3R)-3-[(s)-3-methyl-1-{4-(2,3,4-trimethoxyphenylmethyl)piperazine-1-yl carbonyl}butylcarbamoyl]oxirane-2-carboxylate oxalate as a colorless crystal (yield: 81%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04507297 |
| Source dataset | uspto-grants-1985_03 |
| ORD ID | ord-86436a11c0ca423599950861991a44b3 |
| Source note | uspto-grants-1985_03 |