HRID2164891

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID674

Dimethylamine

C2H7N

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID80170

2,5-Pyrrolidinedione, 1-hydroxy-

C4H5NO3

结构：O=C(O)CCSCC(O)(Cn1cncn1)c1ccc(Cl)cc1Cl

HCID23323745

未命名化合物

PRODUCTS

生成物

结构：CN(C)C(=O)CCSCC(O)(Cn1cncn1)c1ccc(Cl)cc1Cl.CN(C)C(=O)CCSCC(O)(Cn1cncn1)c1ccc(Cl)cc1Cl.Cl.Cl.O

HCID131714175

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

2-(2,4-Dichlorophenyl)-3-(2-carboxyethylthio)-1-(1H-1,2,4-triazol-1-yl)-propan-2-ol (0.38 g) was suspended in dioxan whilst N-hydroxysuccinimide (0.172 g, 1.5 equiv.) and dicyclohexylcarbodiimide (0.309 g, 1.5 equiv.) were added. The reaction mixture was stirred overnight (19 hours) at room temperature. Anhydrous dimethylamine (0.09 g, 2.0 equiv.) was added, and stirring continued for 30 minutes.

WORKUP

后处理

additionwere added
stirringstirring
waitcontinued for 30 minutes

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-84a9f3a9a34642f598ba750dbb5c8939
来源数据集: uspto-grants-1985_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04507484
来源说明: uspto-grants-1985_03

反应 SMILES

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:23])([CH2:16][S:17][CH2:18][CH2:19][C:20]([OH:22])=[O:21])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1.O[N:25]1[C:29](=O)CC[C:26]1=O.[CH:32]1([N:38]=[C:39]=NC2CCCCC2)CCCCC1.CNC>O1CCOCC1>[OH2:21].[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:23])([CH2:16][S:17][CH2:18][CH2:19][C:20](=[O:22])[N:25]([CH3:29])[CH3:26])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1.[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:23])([CH2:16][S:17][CH2:18][CH2:19][C:20](=[O:22])[N:38]([CH3:39])[CH3:32])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1.[ClH:1]