1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- → HCID 20237841, compound

HRID 2164905Notes

Reaction equation

HRID 2164905 reaction equation
C1(=O)[N:5]([CH2:6][CH2:7][NH:8][C:9]2[C:10]([CH3:21])=[N:11][N:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:13]=2[CH3:14])C(=O)C2=CC=CC=C12.BrCCN1C(=O)C2=CC=CC=C2C1=O.NC1C(C)=NN(C2C=CC=CC=2)C=1C>>[NH2:5][CH2:6][CH2:7][NH:8][C:9]1[C:10]([CH3:21])=[N:11][N:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:13]=1[CH3:14]

Participants

4

Reactant 3

HCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-HCID 70370103,5-dimethyl-1-phenyl-1H-pyrazol-4-amineHCID 20237850HCID 20237850, compound

Product 1

HCID 20237841HCID 20237841, compound

Procedure

The 4-(2-phthalimidoethylamino)-3,5-dimethyl-1-phenylpyrazole used as starting material is obtained in a manner analogous to that described in Example 1 by reacting N-(2-bromoethyl)-phthalimide with 4-amino-3,5-dimethyl-1-phenylpyrazole. After chromatographic purification on a silica gel column (methylene chloride-ethyl acetate 6:4 v/v), it is obtained in a yield of 56% of theory in the form of a light brownish colored oil.

Workup

  1. customis obtained in a manner analogous to
  2. customAfter chromatographic purification on a silica gel column (methylene chloride-ethyl acetate 6:4 v/v)
  3. customit is obtained in a yield of 56% of theory in the form of a light brownish colored oil

Sources & evidence

ORD record
ord-a0c7af4c2a3447a98b9caa28720e7dfc
Source dataset
uspto-grants-1985_03
Patent number
US04507488

Reaction notes

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