Potassium Carbonate → HCID 15630314, compound

Participants

Reaction Steps

Ethyl 2-[(4-trifluoromethoxyphenyl)-1,1-diazanediyl]-(2-fluoro-6-difluoromethoxybenzoyl)acetate (530 mg), and potassium carbonate (157 mg) were added to N,N-dimethylformamide (10 ml), and the resultant mixture was heated at 100° C. for 1 hour. The mixture was cooled to room temperature, and was poured into ice-water (about 50 ml). After allowing it to stand for 2 hours, the precipitated crystals were collected by filtration. The crystals were washed with water (5 ml) two times and were dried under reduced pressure to give 478 mg of desired ethyl 1-(4-trifluoromethoxyphenyl)-1,4-dihydro-4-oxo-5-difluoromethoxycinnoline-3-carboxylate (yield: 94.3%). m.p., 145° C.

Provenance & Evidence