Benzenesulfonyl chloride, 4-chloro-3-nitro- → HCID 14324551, compound

Participants

Reaction Conditions

Reaction Steps

1 liter of dichloromethane was added to 800 g of 4-chloro-3-nitrobenzenesulfonyl chloride and the solution was cooled to 0° C. To the solution was added dropwise a mixture of 600 g of hexadecylamine, 251 ml of triethylamine and 780 ml of dichloromethane at 20° to 30° C. After the reaction mixture was reacted for 2 hours at room temperature, the dichloromethane was distilled off under reduced pressure, and 3 liters of methanol was added to the residue followed by heating to dissolve it. The solution was cooled gradually and after crystals were precipitated at room temperature, 3 liters of methanol was added thereto to further facilitate the crystallization under cooling with ice water, and the crystals were filtered and dried.

Provenance & Evidence