Ethyl 2-oxopyrrolidine-1-acetate → HCID 131716451, compound

HRID 2165040Notes

Reaction equation

HRID 2165040 reaction equation
[NH2:1][CH:2]([Si:11]([CH3:14])([CH3:13])[CH3:12])[C:3]12[CH2:10][CH2:9][CH2:8][N:7]1[CH2:6][CH2:5][CH2:4]2.[O:15]=[C:16]1[CH2:20][CH2:19][CH2:18][N:17]1[CH2:21][C:22](OCC)=[O:23]>>[O:15]=[C:16]1[CH2:20][CH2:19][CH2:18][N:17]1[CH2:21][C:22]([NH:1][CH:2]([C:3]12[CH2:4][CH2:5][CH2:6][N:7]1[CH2:8][CH2:9][CH2:10]2)[Si:11]([CH3:14])([CH3:13])[CH3:12])=[O:23]

Participants

3

Reactant 2

HCID 109094Ethyl 2-oxopyrrolidine-1-acetateHCID 131716452HCID 131716452, compound

Product 1

HCID 131716451HCID 131716451, compound

Conditions

Temperature
80 °C

Procedure

A mixture of 150 mg (0.706 mmol) of 7a-[(amino)(trimethylsilyl)methyl]pyrrolizidine and 133 mg (0.777 mmol) of ethyl 2-oxo-1-pyrrolidineacetate was stirred at 80° C. for 5 hours. After cooled, the reaction mixture was chromatographed on alumina column to afford 95.3 mg

Workup

  1. temperatureAfter cooled
  2. customthe reaction mixture was chromatographed on alumina column
  3. customto afford 95.3 mg

Sources & evidence

ORD record
ord-de56bead9fbc4721953d82c37a7cd6ff
Source dataset
uspto-grants-1990_07
Patent number
US04939126

Reaction notes

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