Bromotrimethylsilane → HCID 23043560, compound

HRID 2165046Notes

Reaction equation

HRID 2165046 reaction equation
[N:1]1([CH2:6][CH:7]([P:16]([O:21]CC)(=[O:20])[O:17]CC)[P:8]([O:13]CC)(=[O:12])[O:9]CC)[CH:5]=[CH:4][CH:3]=[N:2]1.[N:24]1([CH2:29][CH:30]([P:39]([O:44]CC)(=[O:43])[O:40]CC)[P:31]([O:36]CC)(=[O:35])[O:32]CC)[CH:28]=[CH:27][N:26]=[CH:25]1.C[Si](C)(C)Br>CO>[N:1]1([CH2:6][CH:7]([P:8]([OH:13])(=[O:9])[OH:12])[P:16]([OH:20])(=[O:17])[OH:21])[CH:5]=[CH:4][CH:3]=[N:2]1.[N:24]1([CH2:29][CH:30]([P:31]([OH:36])(=[O:32])[OH:35])[P:39]([OH:43])(=[O:40])[OH:44])[CH:28]=[CH:27][N:26]=[CH:25]1

Participants

6

Reactant 3

HCID 76113BromotrimethylsilaneHCID 14063998HCID 14063998, compoundHCID 23043566HCID 23043566, compound

Product 2

HCID 23043560HCID 23043560, compoundHCID 23043575HCID 23043575, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The procedure of Example 9 is repeated, starting from tetraethyl 2-(pyrazol-1-yl)ethane-1,1-diphosphonate and tetraethyl 2-(imidazol-1-yl)ethane-1,1-diphosphonate. Treatment with trimethylbromosilane and working up with aqueous methanol gives 2-(pyrazol-1-yl)ethane-1,1-diphosphonic acid, m.p. 227° C. (dec.), and 2-(imidazol-1-yl)ethane-1,1-diphosphonic acid, m.p. 255° C. (dec.).

Sources & evidence

ORD record
ord-73c22cf5d1ba4681964330f8d58ee85b
Source dataset
uspto-grants-1990_07
Patent number
US04939130

Reaction notes

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