Sodium Hydroxide → HCID 178526983, compound

HRID 2165049Notes

Reaction equation

HRID 2165049 reaction equation
[OH-:1].[Na+:2].[C:3]1([C:9]2[NH:10][CH:11]=[C:12]([CH2:14][C:15]([OH:24])([P:20]([OH:23])(=[O:22])[OH:21])[P:16]([OH:19])(=[O:18])[OH:17])[N:13]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>O>[OH2:17].[OH2:1].[C:3]1([C:9]2[NH:10][CH:11]=[C:12]([CH2:14][C:15]([OH:24])([P:20]([OH:22])(=[O:21])[OH:23])[P:16]([O-:19])(=[O:17])[O-:18])[N:13]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[Na+:2].[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178527084HCID 178527084, compound

Product 1

HCID 178526983HCID 178526983, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

10 ml of 2N aqueous sodium hydroxide solution are added, with stirring, to a suspension of 3,36 g of 2-(2-phenylimidazol-4-yl)-1-hydroxy-ethane-1,1-diphosphonic acid in 10 ml of water. The resulting solution is evaporated to dryness. The residue is triturated with 40 ml of methanol. The crystalline precipitate formed is filtered off and dried yielding disodium 2-(2-phenylimidazol-4-yl)-1-hydroxyethane-1,1-diphosphonate-dihydrate m.p. 281°-283° C. (dec.).

Workup

  1. customThe resulting solution is evaporated to dryness
  2. customThe residue is triturated with 40 ml of methanol
  3. customThe crystalline precipitate formed
  4. filtrationis filtered off
  5. customdried

Sources & evidence

ORD record
ord-c0a82440ee6847bfa52cf4538eaf948f
Source dataset
uspto-grants-1990_07
Patent number
US04939130

Reaction notes

Loading…