Zopolrestat → HCID 23667917, compound

HRID 2165072Notes

Reaction equation

HRID 2165072 reaction equation
C[O-].[Na+:3].[F:4][C:5]([F:32])([F:31])[C:6]1[CH:7]=[CH:8][C:9]2[S:13][C:12]([CH2:14][N:15]3[C:24](=[O:25])[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[C:17]([CH2:26][C:27]([OH:29])=[O:28])=[N:16]3)=[N:11][C:10]=2[CH:30]=1>CO>[F:31][C:5]([F:4])([F:32])[C:6]1[CH:7]=[CH:8][C:9]2[S:13][C:12]([CH2:14][N:15]3[C:24](=[O:25])[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[C:17]([CH2:26][C:27]([O-:29])=[O:28])=[N:16]3)=[N:11][C:10]=2[CH:30]=1.[Na+:3]

Participants

4

Reactant 2

HCID 1613ZopolrestatHCID 10942334Sodium Methoxide

Product 1

HCID 23667917HCID 23667917, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sodium methoxide (54 mg) was added to 3-(5-trifluoromethylbenzothiazol-2-ylmethyl)-4-oxo-phthalazin-1-ylacetic acid (0.4 g) in methanol 10 ml) at room temperature. After the addition was complete, a clear solution was obtained which was stirred for 15 minutes at room temperature. The excess methanol was evaporated. The residue was triturated with ether (20 ml) and filtered to obtain the product (0.43 g; m.p. 300° C.).

Workup

  1. additionAfter the addition
  2. customa clear solution was obtained which
  3. customThe excess methanol was evaporated
  4. customThe residue was triturated with ether (20 ml)
  5. filtrationfiltered
  6. customto obtain the product (0.43 g; m.p. 300° C.)

Sources & evidence

ORD record
ord-865de1fad99c453f9c666b56222ceb92
Source dataset
uspto-grants-1990_07
Patent number
US04939140

Reaction notes

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