2-Chloro-1,1,1-triethoxyethane → 2-(Chloromethyl)-[1,3]thiazolo[5,4-b]pyridine

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Reaction Steps

2-Chloromethyl-thiazolo[5,4-b]pyridine was prepared similarly by heating a mixture of 3-amino-2-mercaptopyridine (3.6 g), 2-chloro-1,1,1-triethoxyethane (6.5 g) and ethanol (60 ml) at 60° C. for 4 hours. The crude solid resulting from evaporation of ethanol was chromatographed over silica gel to obtain 2.94 g of the product, m.p. 71°-73° C.

Provenance & Evidence