HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acrylate → N-(3-Methoxy-2-methyl-3-oxopropyl)-N-(phenylmethyl)-beta-alanine ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acrylate | HCID 8821 | — |
| Reactant | Methyl 2-methyl-3-[(phenylmethyl)amino]propanoate | HCID 97781 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(3-Methoxy-2-methyl-3-oxopropyl)-N-(phenylmethyl)-beta-alanine ethyl ester | HCID 98098 | 95% |
Reaction Steps
3-Phenylmethylamino-2-methyl-propanoic acid methyl ester (79 g, 0.38 mole) from Example and ethyl acrylate (54.2 ml, 50.06 g, 0.5 mole) were dissolved in 200 ml of methanol and then heated to reflux overnight. After being cooled, the solution was concentrated under vacuum to remove the excess of solvent and ethyl acrylate to yield the crude N-[2-(methoxycarbonyl)propyl]-N-[2-(ethoxycarbonyl)ethyl]phenylmethylamine (110 g, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04939161 |
| Source dataset | uspto-grants-1990_07 |
| ORD ID | ord-71f8e7accec348169f1cfd8323f4d80d |
| Source note | uspto-grants-1990_07 |