反应详情

5.0 g (26.0 mmol) of crude 2-(6-methoxyindan-1-yl)ethanol are dissolved in 50 ml of dichloromethane and, while cooling with ice, 3.6 g (31 mmol) of methanesulphonic acid chloride and 3.1 g (31 mmol) of triethylamine are added dropwise. The mixture is stirred at room temperature for 3 hours, the triethyl-ammonium chloride which has precipitated is filtered off and the filtrate is extracted by shaking with ice-water. The organic phases are washed with saturated sodium chloride solution, dried over magnesium sulphate and concentrated by evaporation at 40° under reduced pressure. Methanesulphonic acid 2-(6-methoxyindan-1-yl)ethyl ester is obtained which can be used without further purification.

1. additionare added dropwise
2. customthe triethyl-ammonium chloride which has precipitated
3. filtrationis filtered off
4. extractionthe filtrate is extracted
5. stirringby shaking with ice-water
6. washThe organic phases are washed with saturated sodium chloride solution
7. dry with materialdried over magnesium sulphate
8. concentrationconcentrated by evaporation at 40° under reduced pressure