Acetic Acid → HCID 14405001, compound

Participants

Reaction Steps

20 g of 2,6-dichloro-3,5-difluorophenol are introduced into 70 ml of acetic acid, and 8 g of 98% strength nitric acid are added dropwise. The mixture is subsequently stirred for a further 2 hours at room temperature and taken up in 150 ml of dichloromethane, and the solution is washed twice with water. After removing the dichloromethane by distillation, 18 g of product remain. 94% purity according to GC analysis. EXAMPLE A6: 2-Chloro-3,5,6-trifluoro-4-nitrophenol

Provenance & Evidence