HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-aminothiophene-3-carboxylate → N-(5-bromopentyl)-N'-(4-carbomethoxythien-3-yl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-aminothiophene-3-carboxylate | HCID 2777610 | — |
| Reactant | 1-Bromo-5-isocyanatopentane | HCID 14482883 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-(5-bromopentyl)-N'-(4-carbomethoxythien-3-yl)urea | HCID 15697668 | 98% |
Reaction Steps
Methyl 4-aminothiophene-3-carboxylate was reacted with one equivalent of 5-bromopentylisocyanate in toluene at room temperature for 4 hours to produce N-(5-bromopentyl)-N'-(4-carbomethoxythien-3-yl]urea as a tan solid (98%). This material was recrystallized from CH2Cl2 /ether/hexane to afford the urea as a white solid, mp 92°-93.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04939137 |
| Source dataset | uspto-grants-1990_07 |
| ORD ID | ord-00196413812543f780b9ae8faf4dd024 |
| Source note | uspto-grants-1990_07 |