Dimethylformamide → Methyl 3-[3-[4-[4(3-trifluoromethylpheny)piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoate

Participants

Reaction Steps

The title compound was produced following the procedure of Example 1 using 4.28 g (9.5 mmol) of 3-[4-[4-(3-trifluoromethylphenyl)piperazin-1-yl]butyl]thieno[3,4-d]pyrimidine-2,4-dione in DMF at 45° C. for 16 hours to produce methyl 3-[3-[4-[4(3-trifluoromethylpheny)piperazin-1-yl]butyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoate in 80.5% yield (4.1 g).

Provenance & Evidence