Methyl Acrylate → HCID 15070690, compound

Participants

Reaction Steps

The title compound was prepared by starting with 3-[2-[4-(bis(4-fluorophenyl)methylene]piperidin-1-yl]ethyl]thieno[3,4-d]pyrimidine-2,4-dione. This material (7.48 g, 16 mmol) was reacted with methyl acrylate as described in Example 1 to produce 5.48 g (62%) of methyl 3-[3-[2-[4-[bis(4-fluorophenyl)methylene]piperidin-1-yl]ethyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoate as a cream-colored solid after recrystallization from CH2Cl2 /ether/hexane, mp 111°-114° C.

Provenance & Evidence