反应详情

To a solution of N-benzyloxycarbonyl-L-threonine (5 g) in acetic acid (50 ml) was added acetyl bromide (1.75 ml) at room temperature. After stirring for an hour at room temperature, the reaction mixture was concentrated and the residue was diluted with ethyl acetate and washed successively with water (2 times) and brine. After drying over sodium sulfate, the ethyl acetate extract was filtered and concentrated to give O-acetyl-N-benzyloxycarbonyl-L-threonine (3.64 g).

1. concentrationthe reaction mixture was concentrated
2. additionthe residue was diluted with ethyl acetate
3. washwashed successively with water (2 times) and brine
4. dry with materialAfter drying over sodium sulfate
5. extractionthe ethyl acetate extract
6. filtrationwas filtered
7. concentrationconcentrated