Piperidin-3-amine → cis-dichloro-(3RS)-3-aminopiperidine platinum (II)

HRID 2165251Notes

Reaction equation

HRID 2165251 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][CH2:5][NH:4][CH2:3]1.[Cl-:8].[K+].[Pt+2:10].[Cl-:11].[Cl-]>O>[Pt+2:10].[Cl:8][C@H:3]1[C@@H:2]([NH2:1])[CH2:7][CH2:6][CH2:5][N:4]1[Cl:11]

Participants

4

Reactant 2

HCID 148119Piperidin-3-amineHCID 86744074platinum (II) potassium chloride

Product 1

HCID 86744076cis-dichloro-(3RS)-3-aminopiperidine platinum (II)Yield 69.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of (3RS)-3-aminopiperidine (1.7 g) in water (1000 ml) is added platinum (II) potassium chloride (7.2 g) and the mixture is stirred at room temperature for 40 hours. The precipitated solid is removed by filtration, and the filtrate is concentrated under reduced pressure. To the residue is added a small amount of water, and the resulting crystals are separated by filtration and washed with water and acetone to give cis-dichloro-(3RS)-3-aminopiperidine platinum (II) (4.3 g) as pale yellow crystal.

Workup

  1. customThe precipitated solid is removed by filtration
  2. concentrationthe filtrate is concentrated under reduced pressure
  3. additionTo the residue is added a small amount of water
  4. customthe resulting crystals are separated by filtration
  5. washwashed with water and acetone

Sources & evidence

ORD record
ord-d69672ea52474238b177f5708c7dca37
Source dataset
uspto-grants-1990_07
Patent number
US04939256

Reaction notes

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