HCID 53862937, compound → N-(4-pivaloyloxymethoxycarbonyl-2,4-(R*,R*)-dibenzylbutyryl)-3-aminopropionic acid

HRID 2165300Notes

Reaction equation

HRID 2165300 reaction equation
C([O:8][C:9](=[O:43])[CH2:10][CH2:11][NH:12][C:13](=[O:42])[C@@H:14]([CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[CH2:15][C@@H:16]([C:24]([O:26][CH2:27][O:28][C:29](=[O:34])[C:30]([CH3:33])([CH3:32])[CH3:31])=[O:25])[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)C1C=CC=CC=1>C(O)C.[Pd]>[C:29]([O:28][CH2:27][O:26][C:24]([C@@H:16]([CH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[CH2:15][C@H:14]([CH2:35][C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1)[C:13]([NH:12][CH2:11][CH2:10][C:9]([OH:43])=[O:8])=[O:42])=[O:25])(=[O:34])[C:30]([CH3:33])([CH3:32])[CH3:31]

Participants

4

Reactant 1

HCID 53862937HCID 53862937, compound

Product 1

HCID 54190453N-(4-pivaloyloxymethoxycarbonyl-2,4-(R*,R*)-dibenzylbutyryl)-3-aminopropionic acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

0.92 g of N-[4-pivaloyloxymethoxycarbonyl-2,4-(R*,R*)-dibenzylbutyryl]-3-aminopropionic acid benzyl ester in 20 ml of ethanol is hydrogenated at atmospheric pressure in the presence of 0.1 g of 5% palladium on carbon. The reaction is filtered and evaporated to give N-(4-pivaloyloxymethoxycarbonyl-2,4-(R*,R*)-dibenzylbutyryl)-3-aminopropionic acid.

Workup

  1. filtrationThe reaction is filtered
  2. customevaporated

Sources & evidence

ORD record
ord-de0d0e04f5b14f37896d7b61cec0ce4b
Source dataset
uspto-grants-1990_07
Patent number
US04939261

Reaction notes

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