HRID2165300

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)C(=O)OCOC(=O)[C@@H](Cc1ccccc1)C[C@H](Cc1ccccc1)C(=O)NCCC(=O)OCc1ccccc1

HCID53862937

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)C(=O)OCOC(=O)[C@@H](Cc1ccccc1)C[C@H](Cc1ccccc1)C(=O)NCCC(=O)O

HCID54190453

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

0.92 g of N-[4-pivaloyloxymethoxycarbonyl-2,4-(R*,R*)-dibenzylbutyryl]-3-aminopropionic acid benzyl ester in 20 ml of ethanol is hydrogenated at atmospheric pressure in the presence of 0.1 g of 5% palladium on carbon. The reaction is filtered and evaporated to give N-(4-pivaloyloxymethoxycarbonyl-2,4-(R*,R*)-dibenzylbutyryl)-3-aminopropionic acid.

WORKUP

后处理

filtrationThe reaction is filtered
customevaporated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-de0d0e04f5b14f37896d7b61cec0ce4b
来源数据集: uspto-grants-1990_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04939261
来源说明: uspto-grants-1990_07

反应 SMILES

C([O:8][C:9](=[O:43])[CH2:10][CH2:11][NH:12][C:13](=[O:42])[C@@H:14]([CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[CH2:15][C@@H:16]([C:24]([O:26][CH2:27][O:28][C:29](=[O:34])[C:30]([CH3:33])([CH3:32])[CH3:31])=[O:25])[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)C1C=CC=CC=1>C(O)C.[Pd]>[C:29]([O:28][CH2:27][O:26][C:24]([C@@H:16]([CH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[CH2:15][C@H:14]([CH2:35][C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1)[C:13]([NH:12][CH2:11][CH2:10][C:9]([OH:43])=[O:8])=[O:42])=[O:25])(=[O:34])[C:30]([CH3:33])([CH3:32])[CH3:31]