Hydrochloric Acid → HCID 67894110, compound

Participants

Reaction Steps

In a mixture of THF (10 ml) and DMF (1 ml) was dissolved methoxycarbonylphenylmethyl 4-undecyloxyphenylacetate (1.4 g, 3 mmol.). To the solution was added at room temperature potassium tertiary butoxide (1.5 g, 0.012 mol.) The mixture was stirred at room temperature for one hour, to which was added 2N HCl (30 ml), followed by extraction with ethyl acetate. The organic layer was washed with water, dried and concentrated under reduced pressure Resultant crude crystals were recrystallized from IPE-ethyl acetate to give 2-(4-undecyloxyphenyl)-3-hydroxy-4-phenyl-2-buten-4-olide (4-g, 0.9 g, 69%). Physico-chemical properties and NMR spectrum of this compound are shown in Table 7.

Provenance & Evidence