Benzenesulfonyl chloride → HCID 15718670, compound

Participants

Reaction Steps

106 mg (0.5mM) of the product of Step 3, above, in 5 ml of absolute THF is cooled to -78°. 0.328 ml (0.525mM) of 1.6M n-butyllithium in hexane is added and the mixture stirred for 1 hour whilst allowing the temperature to rise to 0°. The mixture is then re-cooled to -60° and 97mg (0.55mM) of benzenesulfonyl chloride is added. After allowing to warm to RT overnight, the mixture is quenched with aqueous NaHCO3 and extracted with ethyl acetate. After washing with NaHCO3 the mixture is dried over Na2SO4 and evaporated to dryness. The residue is triturated with ether and the solids produced precipitated and dried to produce the title product of this step.

Provenance & Evidence