Ethyl formate → HCID 15718671, compound

Participants

Reaction Steps

35.2mg (0.lmM) of the product of Step 4, above, in 4ml of absolute THF is cooled to -40° to -50°. To this is then slowly added 0.075ml (0.12mM) of n-butyllithium (1.6M in hexane) and the mixture stirred for 1 hour at -40° to -50°. 0.1 ml (1.2mM) of ethyl formate is added with stirring for 2 hours at -40° to -50°. The mixture is quenched with aqueous ammonium chloride and extracted with ethyl acetate. The resulting solution is dried over Na2SO4 and evaporated to dryness. The resulting product is applied to prep plates in CH2Cl2 /CH3OH (98:2) and the bands eluted with ethyl acetate to give the title product of this step as a yellow gum.

Provenance & Evidence