3,5-Dimethylisoxazole → Isoxazole, 5-(5-chloro-3-pentynyl)-3-methyl-

HRID 2165439Notes

Reaction equation

HRID 2165439 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[O:4][N:3]=1.[Cl:8][CH2:9][C:10]#[C:11][CH2:12]Cl.C([Li])CCC>>[Cl:8][CH2:9][C:10]#[C:11][CH2:12][CH2:7][C:5]1[O:4][N:3]=[C:2]([CH3:1])[CH:6]=1

Participants

4

Reactant 3

HCID 93123,5-DimethylisoxazoleHCID 131821,4-Dichloro-2-butyneHCID 178418339Butyllithium

Product 1

HCID 9989916Isoxazole, 5-(5-chloro-3-pentynyl)-3-methyl-

Procedure

The intermediate 5-(5-chloro-3-pentynyl)-3-methylisoxazole was prepared from 3,5-dimethylisoxazole and 1,4-dichloro-2-butyne in the presence of n-butyllithium.

Sources & evidence

ORD record
ord-66c5a96c58ab4e30bc6783df3f7fae85
Source dataset
uspto-grants-1990_07
Patent number
US04939267

Reaction notes

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