Sodium hydride → HCID 23042892, compound

Participants

Reaction Steps

A solution of 2-(4-amino-3-pyridyloxy)benzoic acid methyl ester (7.5 g) in dimethylformamide (25 ml) was slowly added to a suspension of sodium hydride (60%) oil dispersion, 1.4 g), washed with hexanes, in dimethylformamide (5 ml). After one hr, the reaction mixture was stirred with ice-water and extracted with chloroform. The organic extract was washed with water, saturated sodium chloride solution, dried over anhydrous magnesium sulfate; filtered, and evaporated to 5.5 g (84%) of product. Recrystallization from absolute ethanol gave the analytical sample, mp 253°-254° C.

Provenance & Evidence