Acetic Anhydride → HCID 14835102, compound

HRID 2165530Notes

Reaction equation

HRID 2165530 reaction equation
[C:1]([CH:3]1[C:12](=[O:13])[N:11]2[C:6]([CH:7]=[CH:8][CH:9]=[CH:10]2)=[C:5]2[C:14]([CH2:17][CH2:18][CH3:19])=[N:15][N:16]=[C:4]12)#[N:2].[C:20](OC(=O)C)(=[O:22])[CH3:21]>>[C:20]([N:16]1[C:4]2=[C:3]([C:1]#[N:2])[C:12](=[O:13])[N:11]3[C:6]([CH:7]=[CH:8][CH:9]=[CH:10]3)=[C:5]2[C:14]([CH2:17][CH2:18][CH3:19])=[N:15]1)(=[O:22])[CH3:21]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 70360271HCID 70360271, compound

Product 1

HCID 14835102HCID 14835102, compound

Procedure

A mixture of 80 g of 4-cyano-1-propyl-5H-pyrazolo-[4,3-a]quinolizin-5-one (S-1) and 2.0 l of acetic anhydride was heated under reflux for 18 hours. The solvent was evapolated under reduced pressure and the residual crystals were washed with water (0.5 l), methyl alcohol (0.5 l) and chloroform (0.5 l) successively to give 84 g of 3-acetyl-4-cyano-1-propyl-5H-pyrazolo-[4,3-a]quinolizin-5-one as pale yellow crystals.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. washthe residual crystals were washed with water (0.5 l), methyl alcohol (0.5 l) and chloroform (0.5 l) successively

Sources & evidence

ORD record
ord-94bafea586154140a75458ce6882c163
Source dataset
uspto-grants-1990_07
Patent number
US04940715

Reaction notes

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